It's not alone in being a dreadful place to reside, however: Birmingham, Alabama and Flint, Michigan take the next two spots.
And there are 47 more cities behind them, ranging from the dusty, deprived city of Merced, California, to tourist favorites Philadelphia and Miami Beach, 24/7 Wall Street reported.
To make the list, the site compiled data on the 551 cities that had populations of more than 65,000 in 2015.
It then rated them on a slew of subjects in nine major categories: crime, economy, demography, education, environment, health, housing, infrastructure, and leisure.
Each of those was then split into sub-sections, so 'crime' differentiates between violent and property crime, while 'health' includes the death rate from illnesses as well as how often people are readmitted to hospital.
Other factors included property prices, poverty and unemployment rates, availability of public transportation and the quality of air.
All data came from 2015 figures.
The statistics were given points and weighted, and final scores handed out to each of the cities to see which were the best and worst on offer.
Below are the top ten worst cities, according to the analysis; the full list can be found at the bottom of the page.
1. Detroit, Michigan