Over-the-counter acid reflux drugs could cause depression

Over-the-counter (OTC) acid-reflux drugs may cause depression, new research suggests.

Sufferers of the mental-health condition are significantly more likely to take proton-pump inhibitors (PPIs) every day, a Taiwanese study found.

Although unclear exactly why this association occurs, the researchers believe PPIs may alter guts' bacterial make-up.

Previous research suggests a link between the microbiome and people's mental health.


Although generally considered safe, PPIs have previously been associated with dementia, bone fractures, pneumonia and gut infections.

As well as being available without a prescription at pharmacies, corner shops and supermarkets, doctors dole out more than five million bottles and packets of PPIs every year in England alone to treat severe heartburn.

Around three per cent of adults in the UK suffer from depression every year.

More